z-logo
open-access-imgOpen Access
Çoklu travmalı ve İzole Kafa Travmalı Hastalarda Sistemik İnflamatuar Cevap Sendromu ve Sepsis Gelişiminde PCT, CRP, D-Dimer, Laktat, TNF-α, IL-1β, IL-6, IL-10 Düzeylerinin Karşılaştırılması
Author(s) -
E. Canan Dagli,
Ali Aydın Altunkan,
Handan Birbiçer,
Gülhan Örekici Temel
Publication year - 2012
Publication title -
türk yoğun bakım derneği dergisi/türk yoğun bakım dergisi
Language(s) - English
Resource type - Journals
eISSN - 2146-6416
pISSN - 2147-267X
DOI - 10.4274/tybdd.08208
Subject(s) - medicine , sepsis
Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS), ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis.\udMaterial and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma) aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the ISS, GCS score and growth rates of SIRS and sepsis were recorded.\udResults: It was demonstrated that for patients with isolated head trauma, SIRS (80.6%), sepsis (38.9%) and mortality values (71.4%) were higher and there is a statistically important linear and inverse relationship between ISS and GCS values (p<0.05). During sepsis and SIRS phases, CRP elevated in both groups, whereas PCT only in the polytrauma group. D-Dimer values were investigated high in both groups, but atypically decreased on day 3 in isolated head trauma group. Lactate, TNF-α and, IL-1β were within reference values, IL-6 and IL-10 values were elevated in both groups but were higher in the polytrauma group.\udConclusion: Although multiple variations were detected in serum markers of pro-inflamatory and acute phase proteins, we thought that these are inadequate in predicting mortality and complications such as SIRS and sepsis

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here