Open AccessDesmoplastic neurotropic melanoma: A diagnostic trap
Author(s) -
Rabia Bozdoğan Arpacı,
Tuba Kara,
Ebru Serinsöz,
Yasemin Yuyucu Karabulut,
Didar Gürsoy,
Alper Sarı,
Anıl Özgür,
Taner Arpacı
Publication year - 2015
Publication title -
deri hastalıkları ve frengi arşivi
Language(s) - English
Resource type - Journals
ISSN - 1019-214X
DOI - 10.4274/turkderm.75350
Subject(s) - trap (plumbing) , melanoma , melanoma diagnosis , medicine , dermatology , cancer research , environmental science , environmental engineering
Desmoplastic neurotropic melanoma (DNM) is known as a rare variety of cutaneous melanoma. The authors defined the term ‘neurotropic’ which is used to refer to the associated nevre infiltration or neural differentiation. 74-year-old female applied to a plastic surgery clinic with one year history of a nodule on the left infraorbital skin. The lesion was excised by the surgeons and was sent to the pathology department.. The tumor with spindle cells in a scar like stroma was detected microscopically and diagnosed as a ‘dermatofibroma’. Eight months after surgery a deep-seated nodule recurred at the same place. This nodule was re-excised. In this sample, we saw hypercellularity, atypical mitoses and nerve infiltration of the spindle tumor cells having strong positive staining with S-100 protein and negative staining with HMB-45, so the ultimate diagnosis was DNM.\udThe differential diagnosis of this lesion includes many benign and malignant entities. This is crucial because of the potential for recurrence and metastasis of the lesion