Morfealı hastalarda klinik özellikler, laboratuvar bulguları, seçilen tedavi yöntemi ve takip sonuçları

Objective: Morphea, also known as localized scleroderma, is a rare skin disease of unknown pathogenesis, characterized by fibrosis in the skin and subcutaneous tissue. In this study, we aim to evaluate the demographic features, clinical characteristics, laboratory findings, and response to treatment in patients diagnosed with morphea. \udMaterials and Methods: The findings of fifty eight patients diagnosed with morphea were retrospectively evaluated between 1995-2011. All patients' clinical symptoms, concomitant diseases, symptoms, immunological features and presence of peripheral eosinophilia were investigated. Treatment methods, response to therapy of 40 patients whose treatment continued for 2-12 months were examined. Fourty nine patients (84.5%) were female and 9 patients (15.5%) were male of 58 patients who were diagnosed with morphea. The mean age of patients was 42.33±18.44 years (range: 7-75 years). Diagnosis was made histopathologically in all cases. Borrelia antibodies were negative in all patients enrolling the study. Thirty six patients (62.1%) had plaque type, 17 patients (29.3%) had generalized type, 3 patients (5.2%) had mixed type (linear + plaque) and 2 patients (3.4%) had linear type of morphea. ANA was found to be positive in 12 (26.2%) of 46 patients. Considering the relationship between the clinical types of morphea with ANA, 38.5% of plaque type, 53.8% of generalized type, 7.7% of mixed type patients showed ANA positivity. ANA positivity was statistically significant in patients with generalized morphea (p=0.027). Peripheral eosinophilia was detected in one case in whom lesions were generalized (2.1%). Colchicine therapy was given to 23 cases. Complete and partial response rates are 47.8% and 26.1%, respectively. However, 17.4% of patients remained stable and progression was noted in 8.7% of the cases. \udConclusion: In conclusion, plaque type morphea is the most common type of morphea. ANA positivity was statistically significant in patients with generalized skin lesions. Colchicine is an effective and safe treatment option