Open AccessAntileishmanial Activity of New Synthesized Schiff and Mannich (Morpholine) Base Compounds
Author(s) -
Şahin Direkel,
Yasemin Ünver,
Cihangir Akdemır
Publication year - 2020
Publication title -
türkiye parazitoloji dergisi/türkiye parazitoloji dergisi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.207
H-Index - 18
eISSN - 2146-3077
pISSN - 1300-6320
DOI - 10.4274/tpd.galenos.2020.6900
Subject(s) - leishmania infantum , amastigote , morpholine , chemistry , leishmaniasis , in vivo , visceral leishmaniasis , pharmacology , leishmania , piperazine , biology , organic chemistry , immunology , parasite hosting , microbiology and biotechnology , world wide web , computer science
Leishmaniasis is an important parasitic disease in many countries, including ours. A variety of drugs are currently used for its treatment. However, certain side effects of these drugs, such as teratogenicity, hepatotoxicity and nephrotoxicity, have been reported in some patients. The goal of this research is to determine the antileishmanial effects of eight different previously synthesised compounds containing Schiff and Mannich bases (morpholine) against Leishmania infantum (L. infantum) promastigotes by the liquid microdilution method utilising alamarBlue.