Çok düşük doğum ağırlıklı bebeklerin hastalık ve ölüm oranlarının zaman içerisindeki değişimi

Aim: The aim of this study is to determine mortality and morbidity changes in very low birth weight infants in the last decade in our intensive care unit. Material and Method: Infants with birth weights of 500-1500 g and gestational age of <36 weeks admitted to our clinic between January 2007 and December 2011 (2. period) were examined retrospectively. The obtained data were compared to the results of 2002-2006 (1. period) years. In addition, effects of antenatal steroids on the prognosis of the babies were also investigated in the last group. Results: Two hundred fourty six very low birth weight infants between 2007 and 2011 were studied. The mean gestational age, birth weight and male ratio were 28.9±2,97 weeks, 1119±283 g and 46.7%, respectively. Only the mean gestational age was significantly lower in the second period (p<0,001). Cesarean delivery, regular pregnancy monitoring, and antenatal steroid usage rates were increased significantly in the present study (p values are 0,011, 0.002, 0.001, respectively). Compared with the previous period,the mortality rate significantly decreased from 35.7% to 25.2% (p=0.013). There was no significant difference between the two periods in terms of the incidence of respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, parenchymal hemorrhage, retinopathy of prematurity, and sepsis (p>0.05). Severe respiratory distress syndrome and advanced retinopathy of prematurity were observed with a significantly lower rate in infants whose mothers received antenatal steroids.Conclusions: While early morbidity rates have not changed, mortality rates have been reduced in infants under 1500 g over time. Severe respiratory distress syndrome and advanced retinopathy of prematurity were observed less commonly in the babies whose mothers were given antenatal steroid. (Turk Arch Ped 2013; 48: 102-9