Open AccessEvaluation of Thalamus Area In Essential Tremor Patients With Proton Magnetik Resonance Spectroscopy
Author(s) -
Adile Özkan,
Fatma Candan,
Nihal Işık,
İlknur Aydın Cantürk,
Semra Arı,
Özgür Öztop Çakmak,
Tunahan Ayaz
Publication year - 2015
Publication title -
türk nöroloji dergisi
Language(s) - English
Resource type - Journals
eISSN - 1309-2545
pISSN - 1301-062X
DOI - 10.4274/tnd.67044
Subject(s) - medicine , essential tremor , thalamus , proton magnetic resonance , nuclear magnetic resonance , spectroscopy , physical medicine and rehabilitation , radiology , astronomy , physics
Objective: Although essential tremor (ET) is the most common movement disorder, its pathogenesis is poorly understood. It is suggested that the ventral\udintermediate (VIM) nucleus of the thalamus is important in the pathophysiology disease.\udMaterials and Methods: The present study aimed to evaluate N-acetylaspartate (NAA), choline (cho), and creatinine (Cr) values via proton magnetic resonance\udspectroscopy (H-1 MRS) of the VIM of the thalamus in 16 control patients and 42 patients with ET.\udResults: The mean NAA/Cr and NAA/Cho values of the thalamus VIM nucleus region in patients with ET was statistically significantly lower than the control\udgroup (p=0.001, p=0.005, respectively). In patients with ET, no significant relation was found between NAA/Cr, NAA/Cho values, and age, family history, disease\udduration, tremor severity, dominant extremity localization of tremor, and history of drug use (p>0.05).\udConclusion: Low NAA values in the thalamus region of patients with ET indicate neuron loss and cell death. Neuron loss in the thalamus region has been\udsuggested to play a part in the pathophysiology of the disease, and may indicate that ET is a neurodegenerative disease