Open AccessProtective Role of <i>Diospyros lotus</i> L. in Cisplatin-Induced Cardiotoxicity: Cardiac Damage and Oxidative Stress in Rats
Author(s) -
Neşe Başak Türkmen,
Dilan AŞKIN ÖZEK,
Aslı Taşlıdere,
Osman Çiftçi,
Özlem Saral,
Cemile Ceren Gül
Publication year - 2022
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2021.84555
Subject(s) - tbars , oxidative stress , cisplatin , cardiotoxicity , pharmacology , glutathione peroxidase , superoxide dismutase , glutathione , thiobarbituric acid , antioxidant , chemistry , lipid peroxidation , medicine , endocrinology , toxicity , biochemistry , chemotherapy , enzyme
Cisplatin is a powerful chemotherapeutic drug that is used to treatment a wide variety of cancers. Despite clinical data demonstrating the cardiotoxic effect of cisplatin, few studies have been carried to improve the cardiotoxicity of cisplatin. In cisplatin-induced toxicity, oxidative stress plays a critical role. This study determined the effect of Diospyros lotus L. fruit (DL), a powerful antioxidant plant, on heart damage caused by cisplatin through histological examination and oxidative stress parameters.