Open AccessFolate-Mediated Paclitaxel Nanodelivery Systems: A Comprehensive Review
Author(s) -
Ashwini K. Bawankule,
Amol A. Tatode,
P. S. Patil,
Milind J. Umekar
Publication year - 2023
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2021.26529
Subject(s) - paclitaxel , nanocarriers , medicine , liposome , pharmacology , chemotherapy , cancer research , chemistry , drug , biochemistry
Paclitaxel (PTX) is used as a viable cancer medication in the chemotherapy of breast, ovarian, lung, bladder, neck, head, and esophageal tumors. The focus of this review is to survey various folate-targeting PTX-loaded nanopreparations in both research and clinical applications. There are diverse nanopreparations, including liposomes, micelles, polymeric nanopreparations, lipid nanopreparations, lipoprotein nanocarriers, and other inorganic nanopreparations for folate-associated PTX tumor targeting. Here, the folate targeting PTX-loaded nanopreparations, which have promising results in the constructive treatment of cancer by reducing toxic side-effects and/or improving effectiveness, was mainly reviewed.