Open AccessGemini Curcumin Suppresses Gastric Cancer AGS Cell Proliferation Through Modulation of lncRNA
Author(s) -
Nasim Jabbari,
Salar Hafez Ghoran,
Haniyeh Semsari,
Bashdar Mahmud Hussen,
Esmaeil Babaei
Publication year - 2022
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2021.03502
Subject(s) - curcumin , blot , carcinogenesis , chemistry , real time polymerase chain reaction , cancer , cancer research , cell growth , cell , microbiology and biotechnology , viability assay , biology , gene , biochemistry , genetics
Gemini surfactant nanocurcumin (Gemini-Cur) is a novel formulation of Curcumin (Cur) with dramatic suppressive effects on cancer cells. Here, we investigated the cancer effects of Gemini-Cur in a human gastric adenocarcinoma cell-line (AGS) through the evaluation of the expression of long non-coding RNAs colon cancer-associated transcript-2 ( CCAT2 ) and its downstream c-Myc as known oncogenic modulators of tumorigenesis.