Open AccessDetermination of the Physicochemical Properties of Piroxicam
Author(s) -
Mustafa Çelebi̇er,
Merve Nenni,
Ozan Kaplan,
Emrah Akgeyik,
Mustafa Sinan Kaynak,
Selma Şahin
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2019.82335
Subject(s) - high performance liquid chromatography , chemistry , chromatography , partition coefficient , piroxicam , spectrophotometry , analytical chemistry (journal) , acid dissociation constant , acetonitrile , aqueous solution , organic chemistry , medicine , alternative medicine , pathology
The aim of this study was to determine the acid dissociation constant (pKa) of piroxicam using high performance liquid chromatography (HPLC) and ultraviolet-visible (UV-Vis) spectrophotometry, and to determine the partition coefficient (Log P), distribution coefficient (Log D), and "Log kw" values of piroxicam using HPLC.