Open AccessFormulation and <i>In Vitro</i> Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Technique
Author(s) -
Naile Öztürk,
Aslı Kara,
İmran Vural
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2019.76402
Subject(s) - nanoparticle , mcf 7 , bioavailability , solubility , telmisartan , sonication , emulsion , chemistry , solvent , nuclear chemistry , materials science , nanotechnology , pharmacology , breast cancer , chromatography , organic chemistry , cancer , medicine , human breast , blood pressure , radiology
Telmisartan (TLM) is an antihypertensive drug that has been shown to have antiproliferative effects on cancer cells. It has low solubility and suboptimal oral bioavailability. To investigate the potential anticancer effect of TLM on breast cancer cells, poly (D, L-lactide) (PLA) nanoparticles were formulated with the benefit of improving its solubility.