Open AccessA Controlled Release Theophylline Delivery System Based on a Bilayer Floating System
Author(s) -
John Afokoghene Avbunudiagba,
Christian Arerusuoghene Alalor,
Queen Dorcas Okolocha
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2019.53325
Subject(s) - friability , granulation , bilayer , materials science , tableting , swelling , chromatography , angle of repose , composite material , microcrystalline cellulose , biomedical engineering , chemistry , chemical engineering , ethyl cellulose , polymer , membrane , cellulose , medicine , biochemistry , organic chemistry , engineering
Bilayer floating drug delivery is an approach that helps to overcome the shortcomings of single-layered tablets. There is little or no fluctuation of the drug in the blood stream or tissue, while control is enabled over the time and site of drug release. In the current study, bilayer theophylline matrix tablets were formulated by double compression and evaluated using granules produced by polymeric granulation and simple coacervation techniques.