A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population | Zendy

F. Özdemir | Zendy; Yağmur Kır | Zendy; Kenan Can Tok | Zendy; Bora Başkak | Zendy; H. Sinan Süzen | Zendy

Open Access

A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population

Author(s) -

F. Özdemir,

Yağmur Kır,

Kenan Can Tok,

Bora Başkak,

H. Sinan Süzen

Publication year - 2020

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2019.46793

Subject(s) - genotyping , genotype , turkish population , biology , restriction fragment length polymorphism , allele , genetics , allele frequency , single nucleotide polymorphism , primer (cosmetics) , polymerase chain reaction , polymorphism (computer science) , microbiology and biotechnology , gene , chemistry , organic chemistry

Gene variation in the cholinergic muscarinic receptor 1 (CHRM1) has potential to become a candidate biomarker in the development of several disorders as well as drug response. In this study, a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was developed to determine the C to A single nucleotide polymorphism at position 267 in the CHRM1 gene.

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