Open AccessDevelopment of Bioadhesive Buccal Tablets of Nicorandil Using a Factorial Approach
Author(s) -
Rajendra Kotadiya,
Karan Shah
Publication year - 2020
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2019.09226
Subject(s) - bioadhesive , friability , factorial experiment , buccal administration , mucoadhesion , ethyl cellulose , materials science , chromatography , chemistry , adhesive , dosage form , cinnarizine , polymer , mathematics , pharmacology , composite material , layer (electronics) , medicine , statistics
In the present investigation, bioadhesive buccal tablets were prepared using the sustained-release polymer hydroxypropyl methylcellulose (HPMC) K100M, bioadhesive polymer neem gum, and an impervious backing layer of ethyl cellulose. Nicorandil is sensitive to the first-pass effect; therefore, a buccal-adhesive dosage form can avoid this effect.