Open AccessRapid Stability Indicating HPLC Method for the Analysis of Leflunomide and Its Related Impurities in Bulk Drug and Formulations
Author(s) -
Useni Reddy Mallu,
Venkateswara Rao Anna
Publication year - 2019
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2018.34635
Subject(s) - chromatography , analyte , impurity , chemistry , high performance liquid chromatography , acetonitrile , dosage form , forced degradation , methanol , volumetric flow rate , analytical chemistry (journal) , capacity factor , materials science , reversed phase chromatography , organic chemistry , physics , quantum mechanics
Leflunomide (LFNM) is a drug that belongs to isoxazole derivatives and has immunosuppressive and anti-inflammatory activities. A literature search confirms that there is no method reported for the simultaneous estimation of LFNM and its related impurities A and B in pharmaceutical dosage forms or in bulk drug. Hence the present work aimed to develop a simple stability indicating RP-HPLC method for the separation and quantification of LFNM and its impurities A and B.