Rapid Stability Indicating HPLC Method for the Analysis of Leflunomide and Its Related Impurities in Bulk Drug and Formulations | Zendy

Useni Reddy Mallu | Zendy; Venkateswara Rao Anna | Zendy; Bikshal Babu Kasimala | Zendy

Open Access

Rapid Stability Indicating HPLC Method for the Analysis of Leflunomide and Its Related Impurities in Bulk Drug and Formulations

Author(s) -

Useni Reddy Mallu,

Venkateswara Rao Anna,

Bikshal Babu Kasimala

Publication year - 2019

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2018.34635

Subject(s) - chromatography , analyte , impurity , chemistry , high performance liquid chromatography , acetonitrile , dosage form , forced degradation , methanol , volumetric flow rate , analytical chemistry (journal) , capacity factor , materials science , reversed phase chromatography , organic chemistry , physics , quantum mechanics

Leflunomide (LFNM) is a drug that belongs to isoxazole derivatives and has immunosuppressive and anti-inflammatory activities. A literature search confirms that there is no method reported for the simultaneous estimation of LFNM and its related impurities A and B in pharmaceutical dosage forms or in bulk drug. Hence the present work aimed to develop a simple stability indicating RP-HPLC method for the separation and quantification of LFNM and its impurities A and B.

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