Open AccessDecreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin
Author(s) -
Tengku Siti Hajar Haryuna,
Farhat Farhat,
Siska Indriany
Publication year - 2019
Publication title -
turkish journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.241
H-Index - 14
eISSN - 2148-6247
pISSN - 1304-530X
DOI - 10.4274/tjps.galenos.2018.20981
Subject(s) - curcumin , spiral ganglion , protein kinase c , immunohistochemistry , cochlea , medicine , endocrinology , chemistry , pharmacology , kinase , anatomy , biochemistry
Microcirculation and hemodynamic disturbances, including in the cochlea, are commonly found in diabetic patients. A study on diabetic rats discovered histopathological changes in outer hair cells and the spiral ganglion and mitochondrial damage in the ear. Hyperglycemia can increase the activation of protein kinase C (PKC). Curcumin as an antioxidant also affects the regulation of PKC and Ca 2+ . The aim of this study was to determine the role of curcumin in decreasing PKC expression in the cochlear fibroblasts of diabetic rats.