Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin | Zendy

Tengku Siti Hajar Haryuna | Zendy; Farhat Farhat | Zendy; Siska Indriany | Zendy

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Decreased Protein Kinase C Expression in the Cochlear Fibroblasts of Diabetic Rat Models Induced by Curcumin

Author(s) -

Tengku Siti Hajar Haryuna,

Farhat Farhat,

Siska Indriany

Publication year - 2019

Publication title -

turkish journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.241

H-Index - 14

eISSN - 2148-6247

pISSN - 1304-530X

DOI - 10.4274/tjps.galenos.2018.20981

Subject(s) - curcumin , spiral ganglion , protein kinase c , immunohistochemistry , cochlea , medicine , endocrinology , chemistry , pharmacology , kinase , anatomy , biochemistry

Microcirculation and hemodynamic disturbances, including in the cochlea, are commonly found in diabetic patients. A study on diabetic rats discovered histopathological changes in outer hair cells and the spiral ganglion and mitochondrial damage in the ear. Hyperglycemia can increase the activation of protein kinase C (PKC). Curcumin as an antioxidant also affects the regulation of PKC and Ca 2+ . The aim of this study was to determine the role of curcumin in decreasing PKC expression in the cochlear fibroblasts of diabetic rats.

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