İdyopatik Orbita İnflamasyon Sendromu Ön Tanılı Olgularda Biyopsi Sonuçlarımız

Objectives: To present our biopsy results in patients who were referred to our oculoplastic clinic with an initial diagnosis of idiopathic\udorbital inflammatory syndrome (IOIS).\udMaterials and Methods: We evaluated 22 patients who were referred to our oculoplastic clinic with an initial diagnosis of idiopathic\udorbital inflammation between 2009 and 2013. We performed biopsy on the patients in whom a differential diagnosis was not possible,\udor response to steroid treatment was not satisfactory, or recurrence occurred after steroid treatment. According to the histopathological\udevaluation, treatment protocols were determined.\udResults: The study included 12 male and 10 female patients. Mean age was 45.6 years (range 16-77 years). Inadequate response to\udsteroid treatment or recurrence in 8 patients and difficulty in differential diagnosis in 4 patients were the indications for the biopsy.\udOne patient declined the biopsy. One patient could not be operated on because of the accompanying systemic diseases. We performed\udorbital fat tissue biopsy in 7 patients, lacrimal gland biopsy in 2 patients, and extraocular muscle biopsy in 1 patient. Histopathological\udevaluations demonstrated IOIS in 8 patients. Lymphoma was diagnosed in 2 patients in whom biopsies were taken from the lacrimal\udgland and retrobulbar fat tissue.\udConclusion: We suggest that biopsy should be performed to confirm the diagnosis and to determine the treatment modality in patients\udwith an initial diagnosis of IOIS, when a differential diagnosis is not possible, or response to steroid treatment is not satisfactory, or if\udrecurrence occurs. (Turk J Ophthalmol 2014; 44: 301-5