Keratokonus ve Subklinik Keratokonusun Tespit Edilmesi için Pentacamla Korneal Hacim Ölçümleri

Pur po se: To estimate the sensitivity and specificity of corneal volume (CV) measurements in discriminating keratoconus and subclinical\udkeratoconus from normal corneas.\udMa te ri al and Met hod: Clinical records and Pentacam measurements of ninety-four patients with keratoconus, 36 patients with\udsubclinical keratoconus, and 166 refractive surgery candidates with normal corneas were evaluated retrospectively. CV within 3, 5, 7, and\ud10 mm circles around the central cornea was measured in one eye of each patient, using the Pentacam. CV measurements in keratoconus and subclinical keratoconus were compared with normal corneas. Receiver operating characteristic (ROC) curves were used to determine\udthe test’s overall predictive accuracy and to identify optimal CV cutoff points to maximize sensitivity and specificity in discriminating\udkeratoconus and subclinical keratoconus from normal corneas.\udRe sults: Mean CV within a 3.0 mm circle around the central cornea was statistically lower in keratoconus (3.4±0.2 mm3, p<0.001) and\udsubclinical keratoconus (3.6±0.2mm3, p<0.001) versus normal corneas (3.8±0.3mm3). ROC curve analysis showed high overall predictive\udaccuracy of CV for keratoconus (area under the curve 0.92). Optimal cutoff points were 3.55 mm3 for keratoconus and 3.65 mm3 for\udsubclinical keratoconus. These values provided sensitivity and specificity of 83% and 86%, respectively, for keratoconus, and 61% and\ud74% for subclinical keratoconus.\udDis cus si on: CV within a 3.0 mm circle around the central cornea effectively discriminates keratoconus from normal corneas. However,\udits sensitivity and specificity are lower for subclinical keratoconus diagnosis. (Turk J Ophthalmol 2013; 43: 77-82