Rat Optik Sinir Ezme Modelinde Topikal ve Sistemik Alfa Tokoferol Uygulaması Yoluyla Retina Gangliyon Hücre Korunması

Pur po se: The aim of our study was to investigate the neuroprotective effects of topical α-tocopherol in optic nerve crush model of rat\udand to compare its efficacy with that of systemic α -tocopherol.\udMa te ri al and Met hod: 50 eyes of 25 Wistar albino rats were included. The eyes were divided into six groups. Optic nerve crush was\udperformed in Groups 1, 3, 5. Additionally, systemic and topical α-tocopherol therapies were given to Groups 1 and 3, respectively. No\udtreatment was applied in Group 5. Groups 2, 4, and 6 were the fellow eyes of the animals comprising Groups 1, 3, and 5. Eyes were\udenucleated at day 45 of the study. Retinal ganglion cells (RGCs) were counted with light microscopy.\udRe sults: Mean RGC numbers were 14.5±3.7 (10.3-20) and 27.5±2.6 (24-30) in Groups 5 and 6, respectively (p: 0.001) They were\udmeasured to be 26.6±7.8 (19-45) and 24.6±3.9 (20-32) in Groups 1 and 2 and 21.1±7.1 (11-34) and 27±7.5 (18-42) in Groups 3 and 4\ud(p:0.659, p:0.094, respectively). There was no difference in Groups 2 and 4 compared with Group 6 (p:0.210, p:0.299, respectively).\udDis cus si on: Topical α-tocopherol has a significant neuroprotective effects in optic nerve crush model of rat and may be used in the\udfuture for the treatment of optic neuropathies such as glaucoma. (Turk J Ophthalmol 2013; 43: 161-6