Herpetik Keratit Skarı Nedeniyle Penetran Keratoplasti Yapılan Olguda Latanoprost Kullanımı Sonrası Görülen Allograft Reaksiyonu

A 27-year-old male patient with a corneal scar secondary to herpetic keratitis in the right eye underwent penetrating keratoplasty (PK).\udAt the 14th month of follow-up, latanoprost was started to treat high intraocular pressure which was refractory to treatment. On the 15th\udday of latanoprost use, allograft reaction (AR) developed. Insufficient clinical response despite intensive immunosuppressive therapy made\udus consider the possibility of recurrent herpetic keratouveitis secondary to steroid treatment. The dramatic reduction in the number of\udkeratic precipitates with oral valacyclovir treatment confirmed this diagnosis. The graft remained clear 3 months after the AR treatment.\udInflammation in eyes that had undergone PK jeopardizes the graft success by disrupting the immune privilege of anterior chamber.\udConsidering the effects of prostaglandin analogues on blood-aqueous barrier, latanoprost use might have been related to allograft reaction\udin this case. Another remarkable characteristics of this case was the herpes simplex virus (HSV) reactivation secondary to AR therapy. For\udthis reason, oral acyclovir prophylaxis together with AR therapy would improve graft success in cases with HSV history. (Turk J\udOph thal mol 2012; 42: 150-3