Diabetik Makula Ödeminde MP-1 Mikroperimetri ile Fiksasyon Stabilitesi ve Makuler Duyarlılığın Değerlendirilmesi

Pur po se: To evaluate macular light sensitivity and fixation stability in subjects with clinically significant macular edema (CSME)\udrelated to diabetes mellitus.\udMa te ri al and Met hod: Thirty eyes of 22 patients with CSME, as defined by Early Treatment Diabetic Retinopathy Study, and 32 eyes of\ud32 healthy subjects were enrolled in this study. Microperimetry was performed with the Micro Perimeter MP-1 in both groups. The mean retinal\udsensitivities at central 4°, at central 12° and at central 20° were measured. The mean extent of preferred retinal locus (PRL), fixation stability\udand fixation location were calculated using fixation test in MP-1 microperimeter. Statistical analysis was performed using student t-test and chisquare\udtest.\udRe sults: The mean best-corrected visual acuity (BCVA) was significantly lower in the CSME group than the control group (p<0.001). The\udmean retinal sensitivities at central 4°, 12° and 20° areas were significantly lower in the CSME group compared to the control group (p<0.001,\udfor each central degrees). In subjects with CSME, fixation stability was detected as stable in 8 (26.7%) eyes, relatively unstable in 21 (70%) eyes\udand unstable in 1 (3.3%) eye. Significant decrease was found in fixation stability and fixation location scores in eyes with CSME compared to\udcontrol subjects (p<0.001). The difference of mean extent in PRL between the groups was statistically significant (p<0.001).\udDis cus si on: The macular light sensitivity and fixation stability are affected in patients with CSME. MP-1 micropeimetry might be\udhelpful to evaluate the extent of PRL and useful for evaluation of severity and progression of diabetic macular edema. (Turk J\udOphthalmol 2012; 42: 310-5