Keratokonusta Çapraz Bağlama Tedavisinin Konus Kırıcılığı ve Yüksek Sıralı Korneal Aberasyonlar Üzerine Etkisi

Objectives: To study the effect of corneal collagen cross-linking on conus curvature and corneal aberrations in keratoconus.\udMaterials and Methods: The medical records of thirty-seven eyes of 32 progressive keratoconus patients (17 male, 15 female, mean\udage: 22.13±4.64 years) who had undergone corneal cross-linking were evaluated retrospectively. The change in refractive errors, visual\udacuity on Snellen charts, average keratometry, conus curvature, and corneal aberrations calculated at 6.00 mm pupil size throughout\udthe follow-up time were compared with paired t-test. The correlation of the change in best-corrected visual acuity and in uncorrected\udvisual acuity with the change of the parameters which had statistically significant difference at 18 months was studied with Pearson’s\udcorrelation analysis.\udResults: The best-corrected visual acuity, uncorrected visual acuity, spherical and cylindrical error, average keratometry, conus curvature,\udvertical coma, total corneal aberrations, total higher order aberrations had statistically significant difference at 18 postoperative months\ud(p=0.001). Spherical aberration (p=0.95) and horizontal coma (p=0.78) did not show statistically significant difference at the end\udof follow-up. The change in uncorrected visual acuity correlated with change in conus curvature (r=-0.420, p=0.01) and change in\udcylindrical refraction (r=0.453, p=0.005) at 18 months. The change in best-corrected visual acuity correlated with change in total corneal\udaberrations (r=-0.490, p=0.002), vertical coma (r=0.408, p=0.01), average keratometry (r=-0.386, p=0.02), conus curvature (r=-0.381,\udp=0.02), and total higher order aberrations (r=-0.326, p=0.05) at 18 months.\udConclusion: Corneal collagen cross-linking treatment applied to progressive keratoconus cases induces significant decrease in conus\udcurvature, in total corneal aberrations, and in higher order aberrations, especially in vertical coma, and leads to a prominent visual acuity\udincrease eventually. (Turk J Ophthalmol 2014; 44: 184-9