Open AccessRelevance of Additional Immunohistochemical Markers in the Differential Diagnosis of Small B-Cell Lymphomas: A Case-Control Study
Author(s) -
Hale Kıvrak,
Seher Yüksel,
Can Ateş,
Mustafa Merter,
Gülşah Kaygusuz,
Muhıt Özcan,
Işınsu Kuzu
Publication year - 2022
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.4274/tjh.galenos.2021.2021.0349
Subject(s) - pathology , lymphoma , lymphoplasmacytic lymphoma , medicine , follicular lymphoma , splenic marginal zone lymphoma , marginal zone b cell lymphoma , chronic lymphocytic leukemia , immunohistochemistry , marginal zone , germinal center , differential diagnosis , waldenstrom macroglobulinemia , immunology , leukemia , b cell , antibody
Clinical and pathological differential diagnosis of small B-cell lymphomas (SBCLs) is still controversial and may be difficult due to their overlapping morphology, phenotype, and differentiation to plasma cells. We aimed to examine the expression of the immune receptor translocation-associated protein 1 (IRTA1), myeloid cell nuclear differentiation antigen (MNDA), lymphoid enhancer-binding factor-1 (LEF1), and stathmin 1 (STMN1) markers in SBCL cases involving different sites that may have plasma cell differentiation.