Open AccessHematopoietic Stem Cell Transplantation for Patients with Paroxysmal Nocturnal Hemoglobinuria with or Without Aplastic Anemia: Multicenter Turkish Experience
Author(s) -
Fergün Yılmaz,
Nur Soyer,
Güldane Cengiz Seval,
Sinem Civriz Bozdağ,
Pervin Topçuoğlu,
Ali Ünal,
Leylagül Kaynar,
Gökhan Özgür,
Gülsan Sucak,
Hakan Göker,
Mustafa Velet,
Hakan Özdoğu,
Mehmet Yılmaz,
Emin Kaya,
Ozan Salim,
Burak Devecı,
İhsan Karadoğan,
Güray Saydam,
Fahri Şahin,
Fılız Vural
Publication year - 2021
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.4274/tjh.galenos.2021.2021.0105
Subject(s) - medicine , paroxysmal nocturnal hemoglobinuria , aplastic anemia , eculizumab , hematopoietic stem cell transplantation , bone marrow failure , hemoglobinuria , transplantation , gastroenterology , surgery , anemia , bone marrow , stem cell , haematopoiesis , immunology , complement system , immune system , biology , genetics
Although inhibition of the complement system at different steps is a promising therapy modality in patients with paroxysmal nocturnal hemoglobinuria (PNH), allogeneic hematopoietic stem cell transplantation (HCT) is still the only curative therapy, especially for patients with intractable hemolysis or bone marrow failure. The aim of this study is to evaluate the outcomes of allogeneic HCT in PNH patients with aplastic anemia (PNH-AA) or without.