Open AccessStress induced premature senescence promotes proliferation by activating SENEX and p16INK4a/ Retinoblastoma (Rb) pathway in Diffuse Large B-cell Lymphoma
Author(s) -
Jiyu Wang,
Zhitao Wang,
Huiping Wang,
Zhixiang Wanyan,
Ying Pan,
Fengcai Zhu,
Qianshan Tao,
Zhimin Zhai
Publication year - 2019
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.4274/tjh.galenos.2019.2019.0117
Subject(s) - senescence , cell growth , cancer research , immunophenotyping , lymphoma , western blot , flow cytometry , transfection , diffuse large b cell lymphoma , cell culture , biology , medicine , microbiology and biotechnology , immunology , gene , genetics
Cellular senescence has been thought to be an important barrier to tumor formation. Recent studies have shown that stress-induced premature senescence (SIPS) can promote partial tumor invasion, but how SIPS affects diffuse large B-cell lymphoma (DLBCL) remains inconclusive. This study aimed to address that issue.