Open AccessInvestigation of the Relationship Between Fok1 and Col1A1 Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia
Author(s) -
Melek Erdem,
Özlem Tüfekçi,
Sefa Kızıldağ,
Şebnem Yılmaz,
Deniz Kızmazoğlu,
Berna Eroğlu Filibeli,
Hale Ören
Publication year - 2019
Publication title -
turkish journal of hematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.351
H-Index - 16
ISSN - 1300-7777
DOI - 10.4274/tjh.galenos.2018.2018.0221
Subject(s) - medicine , calcitriol receptor , bone mineral , pediatrics , osteoporosis , gastroenterology , oncology , vitamin d and neurology , endocrinology
In acute lymphoblastic leukemia (ALL), various clinical risk factors and genetic predispositions contribute to the development of bone complications during and after chemotherapy. In this study, we aimed to investigate whether vitamin D receptor ( VDR ) Fok1 and collagen protein Col1A1 Sp1-binding site gene polymorphisms, which are important in bone mineral and matrix formation, have effects on the development of bone abnormalities in childhood ALL survivors.