Open AccessMedullary Thyroid Carcinoma Showing Melanocytic Differentiation: A Report of a Rare Case
Author(s) -
Serap Karaarslan,
Yeşim Ertan,
Mehmet Hüsnü Buğdaycı,
Funda Taşlı,
Durkaya Ören,
Taner Akalın
Publication year - 2015
Publication title -
turkish journal of endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.111
H-Index - 5
ISSN - 1301-2193
DOI - 10.4274/tjem.2630
Subject(s) - medicine , medullary cavity , thyroid carcinoma , pathology , thyroid , medullary carcinoma , carcinoma , dermatology
Medullary thyroid carcinoma (MTC) accounts for 5-10% of all thyroid malignancies. These tumors show variable morphological features, however, to the best of our knowledge, melanocytic differentiation is rare with only 11 reported cases. We report a 44-year-old female who presented to our clinic with neck swelling of a few months. The thyroid fine needle aspiration biopsy results were suspicious, leading to a total thyroidectomy. On microscopic examination, a malignant tumor with melanocytic features was seen. There was no amyloid deposition in the stroma. Immunohistochemical analysis revealed that the tumor cells were positive for calcitonin, melan-A, HMB45, pancytokeratin, chromogranin, carcinoembriyonic antigen; focal positive for S-100; and negative for HBME-1 and thyroglobulin. This tumor was diagnosed as medullary carcinoma with melanocytic differentiation when evaluated with the morphological and immunohistochemical findings. Turk Jem 2015; 19: 72-7