Open AccessIntralesional Use of Chemotherapeutic and Biological Drugs in Dermatology
Author(s) -
Ercan Çalışkan,
İbrahim Özmen,
Gürol Açıkgöz,
Mustafa Tunca
Publication year - 2014
Publication title -
türk dermatoloji dergisi
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.126
H-Index - 5
eISSN - 1308-5255
pISSN - 1307-7635
DOI - 10.4274/tdd.2018
Subject(s) - dermatology , medicine , chemotherapeutic drugs , biological drugs , pathology , chemotherapy , surgery , disease
Intralesional injection applications being used more frequently in the practice of dermatology were primarily developed in order to avoid systemic side effects of steroids. Intralesional applications enable the potent drugs to achieve local effect with regionally high concentrations but without systemic toxicities. Commonly known, chemotherapeutic agents have the potential for many side effects and cytotoxicities with systemic use. Intralesional use of chemotherapeutic drugs is becoming widespread in the treatment of non-melanoma skin cancers in which surgery is contraindicated or may result in functional or cosmetic loss. In this article, intralesional use of chemotherapeutic and biological agents, their advantages and disadvantages, administered dosages as well as efficacy and safety profiles were summarized and it was aimed to encourage intralesional applications to be more frequently used by all dermatologists.\u