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A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwen 18 flourine-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in 18 F-FDG PET/CT. Later, gallium- 68 ( 68 Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes tha 68 Ga-FAPI PET/CT imaging is superior to 18 F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by 18 F-FDG in breast-cancer staging in the future.

A Case with <sup>68</sup>Ga-FAPI Positive and <sup>18</sup>F-FDG Negative Breast Cancer