Open AccessRadiochromatographic Determination of 131I Labeled Eugenol
Author(s) -
Fazilet Zümrüt Biber Müftüler,
Emine Derviş,
Buse Cetkin,
Volkan Tekin,
Ayfer Yurt Kılçar,
Perihan Ünak
Publication year - 2015
Publication title -
molecular imaging and radionuclide therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.292
H-Index - 7
eISSN - 2147-1959
pISSN - 2146-1414
DOI - 10.4274/mirt.24.01.15
Subject(s) - medicine , eugenol , radiochemistry , pharmacology , chemistry , organic chemistry
Phenolic phytochemicals are a broad class of nutraceuticals found in plants which have been extensively researched by\udscientists for medicinal potential. Eugenol, a phenolic natural compound available in the essential oils primarily extracted from\udclove plants, has been exploited for various medicinal applications. It possesses antioxidant, antimutagenic, antigenotoxic,\udanti-inflammatory and anticancer properties. The goal of current study was to extract Eugenol compound from clove plant\udand radiolabel the eugenol with 131I which is a well known radioisotope for imaging and therapy in Nuclear Medicine\udby utilizing iodogen method. The yield of radiolabeling of Eugenol (131I-E) was calculated over 80% by Thin Layer Radio\udChromatography and High Performance Liquid Radio Chromatograpy methods. Structural analysis of Eugenol was confirmed\udby Liguid Chromatography Mass Spectroscopy. Lipophilicity and stability studies were performed. Due to the attachment of\udiodine to Eugenol, radioiodinated Eugenol was more lipophilic. Stability of 131I-E was appropriate for study period.\udAll experimental results suggest that 131I labeled Eugenol compound may be used in the applications of Nuclear Medicine as\uda radiolabeled agent for imaging and therapy on various cancer types