Open AccessOvarian cancer: Pathogenesis and current recommendations for prophylactic surgery
Author(s) -
I Nyoman Gede Budiana,
Michelle Angelina,
Tjokorda Gede Astawa Pemayun
Publication year - 2019
Publication title -
journal of the turkish-german gynecological association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.346
H-Index - 16
eISSN - 1309-0399
pISSN - 1309-0380
DOI - 10.4274/jtgga.galenos.2018.2018.0119
Subject(s) - ovarian cancer , medicine , pathogenesis , disease , incidence (geometry) , cancer , intensive care medicine , prophylactic surgery , bioinformatics , oncology , gynecology , biology , physics , optics
Ovarian cancer is one of the most common gynecologic cancers, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available, which may explain the entire disease. Early detection and primary prevention of ovarian cancer are difficult, mostly due to its heterogeneous nature. Risk factor modification based on epidemiologic data has not significantly reduced the incidence of ovarian cancer. Currently, prophylactic surgical methods have been proposed as the most effective preventive measures for both the high-risk or low-risk populations. Understanding the existing pathogenesis theories and the surgical options available may alter physician’s perspectives and facilitate better decision making.