Open Access<i>SLC30A8</i> Gene rs13266634 C/T Polymorphism in Children with Type 1 Diabetes in Tamil Nadu, India
Author(s) -
Ramasamy Thirunavukkarasu,
Arthur Asirvatham,
Ayyappan Chitra,
Mariakuttikan Jayalakshmi
Publication year - 2019
Publication title -
jcrpe
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.566
H-Index - 35
eISSN - 1308-5735
pISSN - 1308-5727
DOI - 10.4274/jcrpe.galenos.2018.2018.0195
Subject(s) - odds ratio , genotype , medicine , genetics , allele , type 1 diabetes , transmission disequilibrium test , diabetes mellitus , endocrinology , gene , haplotype , biology
Zinc transporter 8 (ZnT8) is a multi-transmembrane protein situated in the insulin secretory granule of the islets of β-cells and is identified as a novel auto-antigen in type 1 diabetes (T1D). The gene coding for ZnT8, solute carrier family 30 member 8 ( SLC30A8 ) is located on chromosome 8q24.11. This study aimed to identify the association of SLC30A8 rs13266634 C/T gene polymorphism with T1D in a sample of T1D children in Tamil Nadu, India.