Open AccessPediatric Reference Intervals for Free Thyroxine and Free Triiodothyronine by Equilibrium Dialysis-Liquid Chromatography-Tandem Mass Spectrometry
Author(s) -
Sonia L. La’ulu,
Kyle J. Rasmussen,
Joely A. Straseski
Publication year - 2016
Publication title -
jcrpe
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.566
H-Index - 35
eISSN - 1308-5735
pISSN - 1308-5727
DOI - 10.4274/jcrpe.2152
Subject(s) - medicine , percentile , free thyroxine , thyroglobulin , triiodothyronine , thyroid disease , thyroid peroxidase , pediatrics , congenital hypothyroidism , endocrinology , newborn screening , thyroid , thyroid function , statistics , mathematics
Thyroid hormone concentrations fluctuate during growth and development. To accurately diagnose thyroid disease in pediatric patients, reference intervals (RIs) should be established with appropriate age groups from an adequate number of healthy subjects using the most exact methods possible. Obtaining statistically useful numbers of healthy patients is particularly challenging for pediatric populations. The objective of this study was to determine non-parametric RIs for free thyroxine (fT4) and free triiodothyronine (fT3) using equilibrium dialysis-high performance liquid chromatography-tandem mass spectrometry with over 2200 healthy children 6 months-17 years of age.