Use of a Ketamine-Propofol Combination During Sedation and Analgesia

Aim: The aim of this study was to evaluate 1:1 mixture of ketamine\udand propofol for sedative/analgesic efficacy, patient comfort and\udpostoperative complications.\udMethods: The anesthesia and nursing records of patients\udwho received ketamine-propofol mixture in Bezmialem Vakıf\udUniversity Hospital between 2009 and 2010 were retrospectively\uddocumented.\udResults: Of the 51 adult patients who received ketamine-propofol\udsedation, 39 patients had ASA 1-2 score while 12 patients had\udASA 3-4 score. No patient had apnea, desaturation, hypotension or\udvomiting. Two patients who had postoperative agitation received\udmidazolam. All patients were transferred to the surgical ward\udwhen Aldrete scores were >8. Surgeon and patient satisfaction\udwere high except in 2 patients.\udConclusion: Ketamine and propofol mixture for the purpose\udof sedation and analgesia is a practical method with minimal\udnegative effects on respiration and hemodynamic variables,\udhowever, hallucination associated with ketamine may be observed.\udWe conclude that due to the lack of hypnotic activity, 1/2 or 1/3\udinstead of 1/1 ketamine and propofol mixture would be more\udappropriate. (The Medical Bulletin of Haseki 2015; 53:41-6