Open AccessThe Significance of Tumor Budding and Immunohistochemical Axl Expression in Gallbladder Adenocarcinomas
Author(s) -
Özden Öz,
Asuman Argon,
Tülü Kebat,
Çisem Namlı Akıncı,
Özlem Özdemır
Publication year - 2022
Publication title -
balkan medical journal/balkan medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 16
eISSN - 2146-3131
pISSN - 2146-3123
DOI - 10.4274/balkanmedj.galenos.2022.2021-9-37
Subject(s) - tumor budding , immunohistochemistry , lymphovascular invasion , gallbladder cancer , pathology , perineural invasion , budding , cancer , medicine , biology , cancer research , metastasis , genetics , lymph node metastasis
Tumor budding is a histopathological finding that is accepted as an indicator of epithelial-mesenchymal transformation in many solid tumors. Axl is a Receptor Tyrosine Kinase (RTK) family member and contributes to epithelial-mesenchymal transformation. It has been reported that its overexpression in various solid cancer cells is associated with a poor prognosis. It is claimed that Axl RTK may be the targeted molecule in treating some cancers due to its location in the cell membrane.