Open AccessThe Effects and Mechanisms of the Rapamycin-eluting Stent in Urethral Stricture Prevention in Rabbits
Author(s) -
Teng Zhang,
Wei Zhao,
Tengzhou Ren,
Jie Chen,
Zhiwei Chen,
Yan Wang,
Xinjian Cheng,
Jie Wu,
Zhaoyong Yuan,
Tao He
Publication year - 2021
Publication title -
balkan medical journal/balkan medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 16
eISSN - 2146-3131
pISSN - 2146-3123
DOI - 10.4274/balkanmedj.galenos.2021.2021-4-77
Subject(s) - medicine , stent , urethral stricture , ureteroscopy , urology , restenosis , surgery , fibrosis , esophageal stricture , urethra , ureter , dysphagia
Rapamycin was shown to reduce transforming growth factor β1 (TGF-β1) expression, inhibit the Mammalian target of rapamycin function, and prevent TGF-β1-induced pulmonary fibrosis. Rapamycin-eluting stents (RES) were successfully used to prevent coronary artery restenosis. Urethral stricture is one of the most challenging problems in urology. Thus, combining the pharmacological effects of rapamycin and the mechanical support of the stent on the urethra may prevent urethral stricture formation. However, the use of RES for urethral stricture treatment has not been studied.