Rapid Emergence of Florfenicol-Resistant Invasive Non-Typhoidal Salmonella in China: A Potential Threat to Public Health | Zendy

Zeqiang Zhan | Zendy; Xuebin Xu | Zendy; Libin Chen | Zendy; Yuan Gao | Zendy; Fanliang Zeng | Zendy; Xiaoyun Qu | Zendy; Hongxia Zhang | Zendy; Ming Liao | Zendy; Jianmin Zhang | Zendy

Open Access

Rapid Emergence of Florfenicol-Resistant Invasive Non-Typhoidal Salmonella in China: A Potential Threat to Public Health

Author(s) -

Zeqiang Zhan,

Xuebin Xu,

Libin Chen,

Yuan Gao,

Fanliang Zeng,

Xiaoyun Qu,

Hongxia Zhang,

Ming Liao,

Jianmin Zhang

Publication year - 2019

Publication title -

american journal of tropical medicine and hygiene

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.015

H-Index - 151

eISSN - 1476-1645

pISSN - 0002-9637

DOI - 10.4269/ajtmh.19-0403

Subject(s) - florfenicol , salmonella , microbiology and biotechnology , biology , antibiotic resistance , diarrhea , veterinary medicine , medicine , bacteria , antibiotics , genetics

Infection caused by invasive Salmonella occurs when Salmonella bacteria, which normally cause diarrhea, enter the bloodstream and spread through the body. We report the dramatic increase in florfenicol-resistant invasive non-typhoidal Salmonella (iNTS) in China between 2007 and 2016. Of the 186 iNTS strains isolated during the study period, 34 were florfenicol resistant, most of which harbored known resistance genes. Florfenicol is exclusively used in veterinary medicine in China, but now florfenicol-resistant iNTS is found in clinical patients. This finding indicates that antimicrobial resistance produced in veterinary medicine can be transmitted to humans, which poses a severe threat to public health.

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