Open AccessCase Report: Paracoccidioidomycosis in Solid Organ Transplantation: Disseminated Disease in a Liver Recipient and Literature Review
Author(s) -
Paula M. PeçanhaPietrobom,
Aloísio Falqueto,
Anna Danielle Rodrigues Gandarella,
Júlia Vieira Moyzés,
Karoline Almeida Rangel,
Letícia Balarini Miranda,
Matheus Compart Hemerly,
Renata Scarpa Careta,
Paulo Mendes Peçanha
Publication year - 2019
Publication title -
american journal of tropical medicine and hygiene
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.015
H-Index - 151
eISSN - 1476-1645
pISSN - 0002-9637
DOI - 10.4269/ajtmh.18-1008
Subject(s) - paracoccidioidomycosis , medicine , liver transplantation , transplantation , disease , organ transplantation , rare disease , solid organ , dermatology , mycosis , blastomycosis , surgery , pathology
Paracoccidioidomycosis (PCM) is an endemic systemic mycosis that is of great importance in Latin America. Its occurrence in solid organ transplantation (SOT) is rare, but with high mortality rate. In this report, we describe a case of PCM in a liver transplant recipient 19 months after transplantation. The patient presented with multiple skin abscesses, arthritis, osteolytic lesions, and pulmonary and adrenal involvement. Despite the presence of disseminated disease and the patient's immunosuppressed condition, the patient responded well to prolonged antifungal treatment with no sequelae, thus suggesting that early diagnosis and correct treatment may lead to favorable outcomes in SOT recipients with PCM.
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