Open AccessKey role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma
Author(s) -
Xin Zhang,
Huiguo Ding
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i9.1282
Subject(s) - hepatocellular carcinoma , medicine , hepatitis b virus , mutation , pathogenesis , hepatitis b , chronic hepatitis , virology , virus , chronic liver disease , biomarker , gene , immunology , cancer research , cirrhosis , genetics , biology
Chronic hepatitis B virus (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC). The HBV mutations, which include point mutation, deletion, insertion and truncation mutation of HBV gene in 4 open reading frames (S, C, P, X), are closely associated with HCC pathogenesis. Some mutations accumulated during chronic HBV infection could be regarded as a biomarker to predict the occurrence of HCC. The detection of the mutations in clinical practice could be helpful for defining better preventive and therapeutic strategies and, moreover, predicting the progression of liver disease.