Open AccessUnusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate
Author(s) -
Stephen Ip,
Rachel Jeong,
David F. Schaeffer,
Eric M. Yoshida
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i24.2559
Subject(s) - medicine , cholestasis , chondroitin sulfate , drug , jaundice , glucosamine , chondroitin , liver injury , etiology , gastroenterology , pharmacology , biochemistry , glycosaminoglycan , chemistry , anatomy
Glucosamine (GS) and chondroitin sulfate (CS) are common over-the-counter (OTC) supplements used in the treatment of osteoarthritis. These medications are seemingly safe, but there are increasing reports of hepatotoxicity with these supplements. We reported a unique case of drug-induced cholestasis caused by GS and CS in a combination tablet. The etiology of the jaundice was overlooked despite extensive investigations over a three-month period. Unlike drug-induced hepatocellular injury, drug-induced cholestatic jaundice with GS and CS has only been reported twice before. This case emphasizes the importance of a complete medication history, especially OTC supplements, in the assessment of cholestasis.