Open AccessRoles of lipoprotein receptors in the entry of hepatitis C virus
Author(s) -
Jingya Lyu,
Hitomi Imachi,
Kohji Fukunaga,
Takuo Yoshimoto,
Huanxiang Zhang,
Koji Murao
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i24.2535
Subject(s) - scavenger receptor , medicine , hepatitis c virus , hepatocellular carcinoma , receptor , lipoprotein , cirrhosis , virology , virus , viral entry , ldl receptor , immunology , cancer research , cholesterol , viral replication
Infection by hepatitis C virus (HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multi-step complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type I and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection.