Open AccessEvaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging
Author(s) -
Mohamed Bouattour,
Audrey Payancé,
Johanna Wassermann
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i20.2245
Subject(s) - sorafenib , medicine , hepatocellular carcinoma , oncology , population , intensive care medicine , environmental health
Many years after therapeutic wilderness, sorafenib finally showed a clinical benefit in patients with advanced hepatocellular carcinoma. After the primary general enthusiasm worldwide, some disappointments emerged particularly since no new treatment could exceed or at least match sorafenib in this setting. Without these new drugs, research focused on optimizing care of patients treated with sorafenib. One challenging research approach deals with identifying prognostic and predictive biomarkers of sorafenib in this population. The task still seems difficult; however appropriate investigations could resolve this dilemma, as observed for some malignancies where other drugs were used.