Open AccessInfluence of gut bacteria on development and progression of non-alcoholic fatty liver disease
Author(s) -
Ali Abdul-Hai,
Ali T. Abdallah,
Stephen Malnick
Publication year - 2015
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v7.i12.1679
Subject(s) - fatty liver , medicine , metabolic syndrome , disease , pathogenesis , microbiome , gut flora , population , gastroenterology , pathology , bioinformatics , immunology , physiology , biology , obesity , environmental health
The intestine of the human contains a dynamic population of microbes that have a symbiotic relationship with the host. In addition, there is an effect of the intestinal microbiota on metabolism and digestion. Non-alcoholic fatty liver disease (NAFLD) is a common cause worldwide of hepatic pathology and is thought to be the hepatic manifestation of the metabolic syndrome. In this review we examine the effect of the human microbiome on the components and pathogenesis of the metabolic syndrome. We are now on the threshold of therapeutic interventions on the human microbiome in order to effect human disease including NAFLD.