Open AccessRole of autophagy in differential sensitivity of hepatocarcinoma cells to sorafenib
Author(s) -
Trevan Fischer,
Jin Hee Wang,
Adrian C. Vlada,
Jae Sung Kim,
Kevin E. Behrns
Publication year - 2014
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v6.i10.752
Subject(s) - autophagy , ampk , sorafenib , cell culture , apoptosis , microbiology and biotechnology , viability assay , cancer research , cell , programmed cell death , medicine , biology , hepatocellular carcinoma , phosphorylation , protein kinase a , biochemistry , genetics
To investigate the role of sorafenib (SFN) in autophagy of hepatocellular carcinoma (HCC). We evaluated how SFN affects autophagy signaling pathway in human HCC cell lines.