Open AccessCiclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia
Author(s) -
R Larsen,
Mette Kjær,
Martin Eefsen,
Fin Stolze Larsen,
Peter Nissen Bjerring
Publication year - 2013
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v5.i9.513
Subject(s) - ciclosporin , medicine , portacaval anastomosis , anesthesia , saline , intracranial pressure , transplantation , portal hypertension , cirrhosis
To investigate the neuroprotective potential of ciclosporin during acute liver failure. We evaluated the effect of intrathecally administered ciclosporin on intracranial pressure, brain water content and aquaporin-4 expression in a rat model with acute hyperammonaemia.