Open AccessIohexol plasma and urinary concentrations in cirrhotic patients: A pilot study
Author(s) -
Paul Carrier,
Alexandre Destère,
Baptiste Giguet,
Marilyne Debette-Gratien,
Marie Essig,
Caroline Monchaud,
JeanBaptiste Woillard,
Véronique LoustaudRatti
Publication year - 2022
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v14.i8.1621
Subject(s) - iohexol , medicine , renal function , urology , creatinine , urinary system , plasma clearance , cirrhosis , population , urine , ascites , endocrinology , pharmacokinetics , environmental health
Renal failure is an independent prognostic factor for survival in patients with cirrhosis. Equations to calculate serum creatinine significantly overestimate the glomerular filtration rate (GFR). Plasma clearance of direct biomarkers has been used to improve the accuracy of evaluations of GFR in this population, but no study has simultaneously measured plasma and urinary clearance, which is the gold standard.