Open AccessRegulation of PPAR-γ activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease
Author(s) -
Xiaoyun Li,
PeiXuan Ji,
XiXi Ni,
Yuxin Chen,
Li Sheng,
Min Lian,
Can-Jie Guo,
Jing Hua
Publication year - 2022
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v14.i7.1365
Subject(s) - nonalcoholic fatty liver disease , inflammasome , inflammation , macrophage polarization , endocrinology , medicine , hepatocyte , oxidative stress , fatty liver , unfolded protein response , lipid metabolism , chemistry , macrophage , biochemistry , apoptosis , in vitro , disease
Lipid metabolism disorder and inflammatory-immune activation are vital triggers in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Various studies have shown that PPAR-γ exerts potent anti-inflammatory and immunomodulatory properties. However, little is known about the regulation of PPAR-γ activity in modulating cell crosstalk in NAFLD.