Open AccessDevelopment of the nervous system in mouse liver
Author(s) -
Naoto Koike,
Tomomi Tadokoro,
Yasuharu Ueno,
Satoshi Okamoto,
Tatsuya Kobayashi,
Soichiro Murata,
Hideki Taniguchi
Publication year - 2022
Publication title -
world journal of hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v14.i2.386
Subject(s) - medicine , pathology , bile duct , cytokeratin , immunohistochemistry , intrahepatic bile ducts , fibrous capsule of glisson , anatomy
The role of the hepatic nervous system in liver development remains unclear. We previously created functional human micro-hepatic tissue in mice by co-culturing human hepatic endodermal cells with endothelial and mesenchymal cells. However, they lacked Glisson's sheath [the portal tract (PT)]. The PT consists of branches of the hepatic artery (HA), portal vein, and intrahepatic bile duct (IHBD), collectively called the portal triad, together with autonomic nerves.