Open AccessLiver Kidney Crosstalk: Hepatorenal Syndrome
Author(s) -
Mahmoud Nassar,
Nso Nso,
Luis Medina,
Victoria Ghernautan,
Anastasia Novikov,
Alli El-ijla,
Karim Soliman,
Yungmin Kim,
Mostafa Alfishawy,
Vincent Rizzo,
Ahmed Daoud
Publication year - 2021
Publication title -
world journal of hepatology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v13.i9.1058
Subject(s) - medicine , hepatorenal syndrome , pathophysiology , intensive care medicine , renal function , cardiorenal syndrome , kidney , epidemiology , kidney disease , liver disease , gastroenterology , cirrhosis
The dying liver causes the suffocation of the kidneys, which is a simplified way of describing the pathophysiology of hepatorenal syndrome (HRS). HRS is characterized by reversible functional renal impairment due to reduced blood supply and glomerular filtration rate, secondary to increased vasodilators. Over the years, HRS has gained much attention and focus among hepatologists and nephrologists. HRS is a diagnosis of exclusion, and in some cases, it carries a poor prognosis. Different classifications have emerged to better understand, diagnose, and promptly treat this condition. This targeted review aims to provide substantial insight into the epidemiology, pathophysiology, diagnosis, and management of HRS, shed light on the various milestones of this condition, and add to our current understanding.