Open AccessReview: Pathogenesis of cholestatic liver diseases
Author(s) -
Raquel T. Yokoda,
Eduardo A. Rodríguez
Publication year - 2020
Publication title -
world journal of hepatology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.913
H-Index - 55
ISSN - 1948-5182
DOI - 10.4254/wjh.v12.i8.423
Subject(s) - medicine , primary sclerosing cholangitis , liver transplantation , pathogenesis , cholangiocyte , liver disease , liver injury , intrahepatic bile ducts , cholestasis , gastroenterology , disease , pathology , transplantation , bile duct
Cholestatic liver diseases (CLD) begin to develop after an impairment of bile flow start to affect the biliary tree. Cholangiocytes actively participate in the liver response to injury and repair and the intensity of this reaction is a determinant factor for the development of CLD. Progressive cholangiopathies may ultimately lead to end-stage liver disease requiring at the end orthotopic liver transplantation. This narrative review will discuss cholangiocyte biology and pathogenesis mechanisms involved in four intrahepatic CLD: Primary biliary cholangitis, primary sclerosing cholangitis, cystic fibrosis involving the liver, and polycystic liver disease.